Case report: Cyclosporine A-induced extrapyramidal syndrome following hematopoietic stem cell transplantation

Case report: Cyclosporine A-induced extrapyramidal syndrome following hematopoietic stem cell transplantation

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IntroductionCyclosporine A-associated neurotoxicity has been reported in up to 40% of patients and its wide range of catherine lansfield ombre rainbow clouds eyelet curtains neurological adverse effects have been reported, ranging from mild tremors to fatal leukoencephalopathy.Extrapyramidal (EP) neurotoxicity is a rare manifestation of cyclosporine.Cyclosporine-induced extrapyramidal syndrome remains a rare adverse reaction.Design/methodsA database search was performed for studies in patients from all age groups.We found a total of 10 articles reporting EP as an adverse effect of cyclosporine A.

A total of 16 patients were found, and a thorough review of these patients was performed.A comparison of patients was performed to highlight common clinical presentations, investigations during the symptomatic phase, and prognosis.In addition, we describe an 8-year-old boy who developed cyclosporine-related extrapyramidal signs on day 60 post-hematopoietic stem cell transplantation for beta-thalassemia.ConclusionCyclosporine A can induce neurotoxicity resulting in diverse symptoms.Signs of EP are rare manifestations of cyclosporine neurotoxicity and should be considered when evaluating post-transplant recipients of cyclosporine when they are present with any EP Jeans symptoms.

Discontinuation of cyclosporine results in good recovery in most patients.